In Vitro ADME CROs

10 contract research organizations in our directory list In Vitro ADME as a capability, across 5 countries. 6 report GLP capability and 0 report AAALAC accreditation. Compare their species, services and accreditations below, and contact labs directly from their profiles.

10 CROs 6 GLP 5 countries

About In Vitro ADME

In vitro ADME assays predict how a compound will be absorbed, distributed, metabolized and excreted before it is dosed to animals. The core screening panel covers metabolic stability in liver microsomes or hepatocytes, permeability (Caco-2, MDCK or PAMPA), plasma protein binding, solubility, and CYP inhibition. Later assays add CYP induction, reaction phenotyping, transporter interactions and cross-species metabolite comparison.

Because these assays are fast and inexpensive, they are run on many compounds during lead optimization, and the results guide chemistry as much as candidate selection. Before the IND, drug-drug interaction assays follow the expectations of ICH M12, and metabolite profiling across species supports the choice of toxicology species.

Data quality depends on reagents and controls. Ask which hepatocyte lots and species the lab uses, how intrinsic clearance is scaled to in vivo predictions, and whether in vitro results have been checked against the lab’s own in vivo PK data.

ADME & pharmacokinetics guide →

Showing 10 CROs. Order rotates daily so no lab is permanently listed first.

Pharmacelsus

DE GLP

German DMPK CRO offering in vitro ADME, in vivo pharmacokinetics and bioanalysis for discovery and early development.

In Vitro ADME Bioanalysis In Vivo PK Metabolite Identification Mouse Rat

Laxai Life Sciences

IN

Hyderabad discovery services company offering biology and DMPK support alongside chemistry.

In Vitro ADME In Vivo Efficacy In Vivo PK Mouse Rat

Anthem Biosciences

IN GLP

Bengaluru CRDMO offering discovery services including DMPK, safety and bioanalysis alongside development and manufacturing.

In Vitro ADME Bioanalysis In Vivo PK Toxicology Mouse Rat

Selvita

PL GLP

Polish drug discovery CRO providing integrated chemistry, biology, DMPK and translational research services.

In Vitro ADME Bioanalysis In Vitro Pharmacology In Vivo Efficacy Mouse Rat

Nuvisan

DE GLP

German CRO offering integrated discovery, DMPK, bioanalysis and early development services across sites in Germany and France.

In Vitro ADME Bioanalysis In Vivo Efficacy In Vivo PK Toxicology Mouse Rat

Sai Life Sciences

IN

Integrated CRO-CDMO in India whose discovery biology group provides in vivo pharmacology, DMPK and bioanalysis for small molecule programs.

In Vitro ADME Bioanalysis In Vivo Efficacy In Vivo PK Mouse Rat

Jubilant Biosys

IN

Indian integrated drug discovery CRO offering in vivo pharmacology and DMPK alongside chemistry and biology.

In Vitro ADME In Vivo Efficacy In Vivo PK Oncology Models Mouse Rat

Southern Research

US GLP

Not-for-profit research institute in Birmingham, Alabama providing contract drug discovery and preclinical development, including infectious disease and BSL-3 work, oncology models, ADME, bioanalysis, toxicology and…

In Vitro ADME Bioanalysis In Vivo Efficacy Infectious Disease Models Oncology Models Ferret Hamster Mouse Rat

Sygnature Discovery

GB

Integrated drug discovery CRO in Nottingham with in vivo pharmacology, DMPK and bioanalysis alongside chemistry and biology.

In Vitro ADME In Vivo Efficacy In Vivo PK Inflammation Models Metabolic Disease Models Mouse Rat

Aragen Life Sciences

IN GLP

Integrated discovery and development services company in India offering in vivo pharmacology, DMPK, bioanalysis and safety assessment alongside chemistry and biologics services.

In Vitro ADME Bioanalysis In Vivo Efficacy In Vivo PK Toxicology Dog Mouse Rat

Questions to ask when choosing an In Vitro ADME CRO

  • Which species’ microsomes and hepatocytes do you stock, and how are lots qualified?
  • Are your CYP inhibition and induction assays run to support regulatory DDI submissions?
  • How do you handle compounds with low turnover, high binding or poor solubility?
  • What turnaround do you offer for a standard screening panel?
  • Can you run in vivo PK in the same species so in vitro predictions can be checked?