Biotest Facility
Independent Danish CRO focused on early in vivo pharmacology in rodents, with particular expertise in mouse cancer and immuno-oncology models.
About In Vivo Efficacy
In vivo efficacy studies test whether a drug candidate changes a disease-relevant endpoint in a living animal: tumor growth, blood glucose, pain thresholds, behavior, fibrosis, survival. They are usually the studies that decide which candidate advances and what dose range the IND-enabling program should cover.
The model matters less than how well it is run. The same named model can behave very differently between labs, depending on animal source, induction method, baseline variability and how endpoints are measured. A well-run efficacy study has a validated positive control, randomization and blinded scoring, a group size based on the variability of the primary endpoint, and PK samples from the same animals so that effect can be tied to exposure.
Most efficacy work is non-GLP and moves quickly, so communication matters: agree how interim data will be shared and who decides whether to stop, extend or add a dose group.
In Vivo Efficacy CROs
Showing 73 CROs. Order rotates daily so no lab is permanently listed first.
Gubra
Danish preclinical CRO and peptide discovery company known for metabolic, liver and kidney disease models with AI-supported histology and 3D imaging readouts.
EPO Experimental Pharmacology & Oncology Berlin-Buch
Berlin oncology CRO with a large collection of patient-derived xenograft models for in vivo efficacy and biomarker studies.
Texas Biomedical Research Institute
Independent nonprofit research institute with a national primate research center and high-containment labs, offering contract infectious disease, vaccine and NHP studies.
Transpharmation
Translational neuroscience CRO with sites in the UK, Ireland and Canada offering CNS disease models, EEG and behavioral pharmacology.
Sai Life Sciences
Integrated CRO-CDMO in India whose discovery biology group provides in vivo pharmacology, DMPK and bioanalysis for small molecule programs.
Scantox
GLP-accredited preclinical CRO headquartered in Denmark with sites in Sweden, Austria and the UK. Known for Gottingen minipig work and regulatory toxicology, with discovery pharmacology including CNS and…
Neuron Experts
French neuroscience CRO offering in vitro and in vivo models for neurological and neurodegenerative drug discovery.
Alpha Genesis
Vertically integrated nonhuman primate CRO in South Carolina combining on-site breeding with discovery pharmacology, GLP toxicology, vaccine and gene therapy studies.
TheraIndx Lifesciences
Bengaluru preclinical CRO providing pharmacology, pharmacokinetic and toxicology studies.
Etap-Lab
French preclinical CRO offering in vivo pharmacology in neuroscience, pain and dermatology, plus related safety studies.
K2bio
Houston preclinical CRO near the Texas Medical Center with an AAALAC-accredited mouse vivarium, in vivo pharmacology and flexible lab space.
Sygnature Discovery
Integrated drug discovery CRO in Nottingham with in vivo pharmacology, DMPK and bioanalysis alongside chemistry and biology.
Physiogenex
Preclinical CRO near Toulouse specializing in metabolic disease pharmacology, including obesity, diabetes and NASH/MASH models.
Experimentica
Ophthalmology-focused preclinical CRO offering retinal and anterior segment disease models, ocular dosing and functional readouts.
Hooke Laboratories
Preclinical CRO focused on rodent models of autoimmune and inflammatory disease, such as EAE, arthritis and colitis, with supporting histology, cytokine analysis and flow cytometry.
Turner Scientific
Specialty preclinical CRO focused on hearing research, offering ototoxicity, otoprotection and auditory efficacy studies.
CorestemChemon (ChemOn)
South Korea's first private non-clinical CRO, providing GLP toxicity, safety pharmacology, pharmacokinetic and efficacy studies for drugs, chemicals and biologics.
Virscio
Translational research company using Old World primate models for ophthalmology, CNS and metabolic disease studies, with an AAALAC-accredited primate facility.
Powered Research
Preclinical CRO in the Research Triangle specializing in ophthalmic disease models, ocular dosing and retinal function readouts.
Oregon National Primate Research Center
OHSU national primate research center supporting neuroscience, metabolic, reproductive and infectious disease research, with core services available to outside investigators.
Preclinics
German preclinical CRO offering in vivo pharmacology, pharmacokinetic and exploratory safety studies.
Shanghai LIDE Biotech
Shanghai oncology CRO with patient-derived xenograft and other tumor models for efficacy studies.
Prisys Biotechnologies
Shanghai CRO centered on nonhuman primate efficacy and safety studies, with NHP disease models across metabolism, cardiovascular, renal, neurology and ophthalmology, clinical-style imaging and interventional surgery.
Selvita
Polish drug discovery CRO providing integrated chemistry, biology, DMPK and translational research services.
Laxai Life Sciences
Hyderabad discovery services company offering biology and DMPK support alongside chemistry.
Melior Discovery
In vivo pharmacology CRO near Philadelphia running a broad catalog of efficacy models across CNS, pain, metabolic and inflammatory disease.
Nihon Bioresearch
Japanese preclinical CRO offering GLP safety and efficacy studies for drugs, devices and regenerative products, with long minipig experience.
Beviglia Cancer Models
Small niche oncology pharmacology CRO validating in vivo efficacy of cancer therapies in clinically predictive models.
XenTech
French translational oncology CRO built around patient-derived xenograft models, with drug response and biomarker discovery services.
Vivo Bio Tech
Hyderabad-based preclinical CRO offering GLP toxicology, pharmacology and pharmacokinetic studies across rodent and non-rodent species.
EyeCRO
Ophthalmology-focused preclinical CRO offering ocular efficacy models, formulation screening, ocular PK and tolerability studies.
PharmaLegacy Laboratories
Preclinical pharmacology CRO in Shanghai with specialty efficacy models in autoimmunity, inflammation, bone and orthopedics, oncology and metabolic disease, plus supporting PK/PD and exploratory toxicology.
SynAging
French CRO focused on neurodegeneration and brain aging, offering in vivo models and readouts for Alzheimer's and related diseases.
Keyfronbio (BTT Group)
Korean nonclinical pharmacology CRO in the Biotoxtech group offering efficacy studies, PCR-based biodistribution for cell and gene therapies, and GLP bioanalysis.
Probetex
Specialty CRO focused on preclinical kidney disease models and renal pathology for nephrology drug programs.
Tulane National Primate Research Center
National primate research center with high-containment capability supporting infectious disease, vaccine and translational NHP studies, including sponsored research.
Southern Research
Not-for-profit research institute in Birmingham, Alabama providing contract drug discovery and preclinical development, including infectious disease and BSL-3 work, oncology models, ADME, bioanalysis, toxicology and…
vivoPharm
Preclinical oncology and immuno-oncology CRO with orthotopic and metastatic models, whole-body imaging and GLP toxicology, with sites in Australia and the US.
genOway
Lyon-based company creating genetically engineered and humanized rodent models, with catalog models and in vivo research services.
SMC Laboratories
Tokyo CRO known for NASH/MASH and fibrosis mouse models, with efficacy studies across liver, kidney and metabolic disease.
HLB bioStep (formerly Knotus)
Korean non-clinical CRO focused on efficacy testing of new drug candidates, with research facilities in Songdo, Incheon.
Aragen Life Sciences
Integrated discovery and development services company in India offering in vivo pharmacology, DMPK, bioanalysis and safety assessment alongside chemistry and biologics services.
Comparative Biosciences
Bay Area preclinical CRO offering GLP and non-GLP toxicology, pharmacology and efficacy models with an in-house histopathology lab, including tissue cross-reactivity and histomorphometry.
Biomodels
Preclinical efficacy CRO in the Boston area running predictive animal models across inflammation, mucositis, oncology-supportive care and other indications for biotech and pharma sponsors.
Explora BioLabs
Contract vivarium operator providing turnkey animal housing, husbandry, veterinary and technical research services for biotech teams, with in vivo study support.
Redoxis
Swedish CRO specializing in rodent models of arthritis, autoimmunity and inflammation.
Hera BioLabs
Kentucky CRO developing immunodeficient rat and mouse models, offering xenograft efficacy and safety studies in larger rodent hosts.
ANEWCRO, LLC.
ANEWCRO is a nonclinical contract research organization (CRO) dedicated to providing innovative solutions and support to the biopharmaceutical industry, biotech startups and academic institutions. With unlimited access…
Vibiosphen
French CRO specializing in in vivo infection models for antibacterial and antifungal drug development.
The Jackson Laboratory (JAX In Vivo Services)
Nonprofit mouse genetics institute offering contract in vivo pharmacology using its own strains and humanized and PDX models across oncology, neuroscience, metabolism and immunology.
ZSHK Laboratories
Preclinical CRO with roots in a Chinese Academy of Sciences safety center, offering pharmacology, DMPK and safety evaluation with GLP operations in Shenzhen.
Biomere
Biomere (a JOINN company) is a preclinical CRO based in Worcester, MA. Services include non-GLP PK/PD, discovery toxicology, surgical services, disease models, and laboratory sciences. Surgical services include…
Jubilant Biosys
Indian integrated drug discovery CRO offering in vivo pharmacology and DMPK alongside chemistry and biology.
Antineo
Lyon oncology CRO providing in vitro and in vivo proof-of-concept studies for anticancer agents, including resistant tumor models.
Science in Action
Israeli preclinical CRO offering in vivo pharmacology and disease model studies.
Hamamatsu Pharma Research
AAALAC-accredited Japanese CRO specializing in nonhuman primate disease models for preclinical efficacy and proof of concept.
Neuro-Sys
French neuroscience CRO dedicated to in vitro and in vivo models of neurodegenerative and neurological disease, with a US office.
Cyagen
Animal model company offering custom genetically engineered rodents together with in vivo pharmacology and AAV services, with operations in the US and China.
Cynbiose
Preclinical CRO near Lyon with core expertise in nonhuman primate models, including BSL-3 infectious disease, biodistribution and custom proof-of-concept studies.
IBT Bioservices (Integrated BioTherapeutics)
Maryland CRO specializing in infectious disease and vaccine research, offering in vitro and in vivo efficacy models and immunological assays.
Imanis Life Sciences
Minnesota company providing preclinical services and reagents for oncolytic virus, gene and cell therapy programs, including reporter imaging and efficacy models.
Biocytogen
Beijing-based company providing genetically engineered and humanized mouse models with in vivo pharmacology services, especially for oncology and immunology antibody programs.
GemPharmatech
Chinese provider of genetically engineered mouse models with in vivo pharmacology services across oncology, immunology and metabolic disease.
Certis Oncology Solutions
San Diego oncology CRO offering patient-derived and orthotopic tumor models for in vivo efficacy and translational studies.
Pharmatest Services
Finnish preclinical CRO focused on bone and joint disease, bone metastasis and oncology models, including osteoarthritis and osteoporosis efficacy studies.
Nuvisan
German CRO offering integrated discovery, DMPK, bioanalysis and early development services across sites in Germany and France.
DT&CRO
Korean CRO covering GLP toxicity, PK and efficacy studies through to clinical trials for drugs, devices and other products.
Atlantic Bone Screen
French preclinical CRO specializing in bone, joint and inflammatory disease models with histology and imaging readouts.
Shanghai Model Organisms Center (SMOC)
Shanghai provider of genetically engineered rodent models with phenotyping and in vivo pharmacology services.
Altogen Labs
Texas preclinical CRO offering xenograft and other oncology models, efficacy, pharmacology and toxicology studies.
Kunming Biomed International (KBI)
Southwest China pharmacology CRO specializing in nonhuman primate efficacy, PK/PD and exploratory safety studies.
NAEJA-RGM Pharmaceuticals
Edmonton CRO providing anti-infective drug discovery support, including in vivo infection models and pharmacokinetics.
Questions to ask when choosing an In Vivo Efficacy CRO
- What positive-control data do you have for this model from the past 12 months, and what is the typical effect size and variability?
- How are animals randomized, and is scoring blind to treatment?
- How did you choose group size for the primary endpoint?
- Can PK and biomarker samples be taken from the efficacy animals?
- How quickly will we see interim data, and in what format?