Antineo
Lyon oncology CRO providing in vitro and in vivo proof-of-concept studies for anticancer agents, including resistant tumor models.
About In Vivo Pharmacology
In vivo pharmacology studies test whether a compound does what it was designed to do in a living system: engaging its target, moving a disease-relevant endpoint, and doing so at exposures that can be translated to a clinical dose. They sit between in vitro screening and IND-enabling toxicology, and their results usually decide which candidate moves forward.
The work covers efficacy studies in disease models (oncology xenograft, syngeneic and PDX models, neurodegeneration, pain and behavioral models), dose-response studies, and target engagement or receptor occupancy measurements, often with PK/PD sampling built in. For antibodies and other biologics, the model species must express a target the molecule actually binds, which can narrow the choice of model and lab considerably.
Model validation matters more than the model name. Two labs can offer the same model with very different baseline variability, positive-control history and endpoint methods, so ask for recent control data before comparing on price.
In Vivo Pharmacology CROs
Showing 81 CROs. Order rotates daily so no lab is permanently listed first.
Neuron Experts
French neuroscience CRO offering in vitro and in vivo models for neurological and neurodegenerative drug discovery.
EPO Experimental Pharmacology & Oncology Berlin-Buch
Berlin oncology CRO with a large collection of patient-derived xenograft models for in vivo efficacy and biomarker studies.
Vivo Bio Tech
Hyderabad-based preclinical CRO offering GLP toxicology, pharmacology and pharmacokinetic studies across rodent and non-rodent species.
Texas Biomedical Research Institute
Independent nonprofit research institute with a national primate research center and high-containment labs, offering contract infectious disease, vaccine and NHP studies.
Shanghai Model Organisms Center (SMOC)
Shanghai provider of genetically engineered rodent models with phenotyping and in vivo pharmacology services.
Aragen Life Sciences
Integrated discovery and development services company in India offering in vivo pharmacology, DMPK, bioanalysis and safety assessment alongside chemistry and biologics services.
TheraIndx Lifesciences
Bengaluru preclinical CRO providing pharmacology, pharmacokinetic and toxicology studies.
Preclinics
German preclinical CRO offering in vivo pharmacology, pharmacokinetic and exploratory safety studies.
Science in Action
Israeli preclinical CRO offering in vivo pharmacology and disease model studies.
SMC Laboratories
Tokyo CRO known for NASH/MASH and fibrosis mouse models, with efficacy studies across liver, kidney and metabolic disease.
XenTech
French translational oncology CRO built around patient-derived xenograft models, with drug response and biomarker discovery services.
Porsolt
Preclinical in vivo pharmacology with CNS/behavioral expertise and multiple disease models.
Biospective
Montreal-based neuroscience CRO combining neurodegenerative disease models with MRI imaging, quantitative neuropathology and image analysis.
Alpha Genesis
Vertically integrated nonhuman primate CRO in South Carolina combining on-site breeding with discovery pharmacology, GLP toxicology, vaccine and gene therapy studies.
Keyfronbio (BTT Group)
Korean nonclinical pharmacology CRO in the Biotoxtech group offering efficacy studies, PCR-based biodistribution for cell and gene therapies, and GLP bioanalysis.
IBT Bioservices (Integrated BioTherapeutics)
Maryland CRO specializing in infectious disease and vaccine research, offering in vitro and in vivo efficacy models and immunological assays.
GemPharmatech
Chinese provider of genetically engineered mouse models with in vivo pharmacology services across oncology, immunology and metabolic disease.
Sai Life Sciences
Integrated CRO-CDMO in India whose discovery biology group provides in vivo pharmacology, DMPK and bioanalysis for small molecule programs.
Virscio
Translational research company using Old World primate models for ophthalmology, CNS and metabolic disease studies, with an AAALAC-accredited primate facility.
Neuro-Sys
French neuroscience CRO dedicated to in vitro and in vivo models of neurodegenerative and neurological disease, with a US office.
Turner Scientific
Specialty preclinical CRO focused on hearing research, offering ototoxicity, otoprotection and auditory efficacy studies.
Prisys Biotechnologies
Shanghai CRO centered on nonhuman primate efficacy and safety studies, with NHP disease models across metabolism, cardiovascular, renal, neurology and ophthalmology, clinical-style imaging and interventional surgery.
Hera BioLabs
Kentucky CRO developing immunodeficient rat and mouse models, offering xenograft efficacy and safety studies in larger rodent hosts.
Powered Research
Preclinical CRO in the Research Triangle specializing in ophthalmic disease models, ocular dosing and retinal function readouts.
Etap-Lab
French preclinical CRO offering in vivo pharmacology in neuroscience, pain and dermatology, plus related safety studies.
Probetex
Specialty CRO focused on preclinical kidney disease models and renal pathology for nephrology drug programs.
ANEWCRO, LLC.
ANEWCRO is a nonclinical contract research organization (CRO) dedicated to providing innovative solutions and support to the biopharmaceutical industry, biotech startups and academic institutions. With unlimited access…
Kunming Biomed International (KBI)
Southwest China pharmacology CRO specializing in nonhuman primate efficacy, PK/PD and exploratory safety studies.
Certis Oncology Solutions
San Diego oncology CRO offering patient-derived and orthotopic tumor models for in vivo efficacy and translational studies.
genOway
Lyon-based company creating genetically engineered and humanized rodent models, with catalog models and in vivo research services.
Hamamatsu Pharma Research
AAALAC-accredited Japanese CRO specializing in nonhuman primate disease models for preclinical efficacy and proof of concept.
SynAging
French CRO focused on neurodegeneration and brain aging, offering in vivo models and readouts for Alzheimer's and related diseases.
Pharmatest Services
Finnish preclinical CRO focused on bone and joint disease, bone metastasis and oncology models, including osteoarthritis and osteoporosis efficacy studies.
Imanis Life Sciences
Minnesota company providing preclinical services and reagents for oncolytic virus, gene and cell therapy programs, including reporter imaging and efficacy models.
DT&CRO
Korean CRO covering GLP toxicity, PK and efficacy studies through to clinical trials for drugs, devices and other products.
Biomere
Biomere (a JOINN company) is a preclinical CRO based in Worcester, MA. Services include non-GLP PK/PD, discovery toxicology, surgical services, disease models, and laboratory sciences. Surgical services include…
CorestemChemon (ChemOn)
South Korea's first private non-clinical CRO, providing GLP toxicity, safety pharmacology, pharmacokinetic and efficacy studies for drugs, chemicals and biologics.
HLB bioStep (formerly Knotus)
Korean non-clinical CRO focused on efficacy testing of new drug candidates, with research facilities in Songdo, Incheon.
NAEJA-RGM Pharmaceuticals
Edmonton CRO providing anti-infective drug discovery support, including in vivo infection models and pharmacokinetics.
PharmaLegacy Laboratories
Preclinical pharmacology CRO in Shanghai with specialty efficacy models in autoimmunity, inflammation, bone and orthopedics, oncology and metabolic disease, plus supporting PK/PD and exploratory toxicology.
Melior Discovery
In vivo pharmacology CRO near Philadelphia running a broad catalog of efficacy models across CNS, pain, metabolic and inflammatory disease.
Explora BioLabs
Contract vivarium operator providing turnkey animal housing, husbandry, veterinary and technical research services for biotech teams, with in vivo study support.
Physiogenex
Preclinical CRO near Toulouse specializing in metabolic disease pharmacology, including obesity, diabetes and NASH/MASH models.
Laxai Life Sciences
Hyderabad discovery services company offering biology and DMPK support alongside chemistry.
Scantox
GLP-accredited preclinical CRO headquartered in Denmark with sites in Sweden, Austria and the UK. Known for Gottingen minipig work and regulatory toxicology, with discovery pharmacology including CNS and…
Nuvisan
German CRO offering integrated discovery, DMPK, bioanalysis and early development services across sites in Germany and France.
EyeCRO
Ophthalmology-focused preclinical CRO offering ocular efficacy models, formulation screening, ocular PK and tolerability studies.
Charles River Laboratories
Global preclinical/clinical CRO with extensive safety assessment, pharmacology, and discovery services.
Redoxis
Swedish CRO specializing in rodent models of arthritis, autoimmunity and inflammation.
Lovelace Biomedical
Preclinical in vivo pharmacology and toxicology with aerosol/inhalation expertise.
Atlantic Bone Screen
French preclinical CRO specializing in bone, joint and inflammatory disease models with histology and imaging readouts.
Biomodels
Preclinical efficacy CRO in the Boston area running predictive animal models across inflammation, mucositis, oncology-supportive care and other indications for biotech and pharma sponsors.
PsychoGenics
Preclinical CNS CRO offering behavioral pharmacology, translational neuroscience, EEG and disease models for psychiatric and neurological programs.
Transpharmation
Translational neuroscience CRO with sites in the UK, Ireland and Canada offering CNS disease models, EEG and behavioral pharmacology.
Tulane National Primate Research Center
National primate research center with high-containment capability supporting infectious disease, vaccine and translational NHP studies, including sponsored research.
Comparative Biosciences
Bay Area preclinical CRO offering GLP and non-GLP toxicology, pharmacology and efficacy models with an in-house histopathology lab, including tissue cross-reactivity and histomorphometry.
Oregon National Primate Research Center
OHSU national primate research center supporting neuroscience, metabolic, reproductive and infectious disease research, with core services available to outside investigators.
Biocytogen
Beijing-based company providing genetically engineered and humanized mouse models with in vivo pharmacology services, especially for oncology and immunology antibody programs.
BIOQUAL
Nonclinical CRO supporting infectious disease and other in vivo studies; bioanalysis and pathology support.
Biotest Facility
Independent Danish CRO focused on early in vivo pharmacology in rodents, with particular expertise in mouse cancer and immuno-oncology models.
Sygnature Discovery
Integrated drug discovery CRO in Nottingham with in vivo pharmacology, DMPK and bioanalysis alongside chemistry and biology.
The Jackson Laboratory (JAX In Vivo Services)
Nonprofit mouse genetics institute offering contract in vivo pharmacology using its own strains and humanized and PDX models across oncology, neuroscience, metabolism and immunology.
Noble Life Sciences
Preclinical CRO offering in vivo pharmacology, toxicology, and surgical services.
Nihon Bioresearch
Japanese preclinical CRO offering GLP safety and efficacy studies for drugs, devices and regenerative products, with long minipig experience.
vivoPharm
Preclinical oncology and immuno-oncology CRO with orthotopic and metastatic models, whole-body imaging and GLP toxicology, with sites in Australia and the US.
Shanghai LIDE Biotech
Shanghai oncology CRO with patient-derived xenograft and other tumor models for efficacy studies.
Biotrial
French CRO combining early clinical development with preclinical pharmacology, offering CNS and cardiovascular safety pharmacology and translational neuroscience models.
Vibiosphen
French CRO specializing in in vivo infection models for antibacterial and antifungal drug development.
Altogen Labs
Texas preclinical CRO offering xenograft and other oncology models, efficacy, pharmacology and toxicology studies.
Selvita
Polish drug discovery CRO providing integrated chemistry, biology, DMPK and translational research services.
Gubra
Danish preclinical CRO and peptide discovery company known for metabolic, liver and kidney disease models with AI-supported histology and 3D imaging readouts.
Hooke Laboratories
Preclinical CRO focused on rodent models of autoimmune and inflammatory disease, such as EAE, arthritis and colitis, with supporting histology, cytokine analysis and flow cytometry.
Beviglia Cancer Models
Small niche oncology pharmacology CRO validating in vivo efficacy of cancer therapies in clinically predictive models.
Jubilant Biosys
Indian integrated drug discovery CRO offering in vivo pharmacology and DMPK alongside chemistry and biology.
Experimentica
Ophthalmology-focused preclinical CRO offering retinal and anterior segment disease models, ocular dosing and functional readouts.
Southern Research
Not-for-profit research institute in Birmingham, Alabama providing contract drug discovery and preclinical development, including infectious disease and BSL-3 work, oncology models, ADME, bioanalysis, toxicology and…
Cynbiose
Preclinical CRO near Lyon with core expertise in nonhuman primate models, including BSL-3 infectious disease, biodistribution and custom proof-of-concept studies.
K2bio
Houston preclinical CRO near the Texas Medical Center with an AAALAC-accredited mouse vivarium, in vivo pharmacology and flexible lab space.
Cyagen
Animal model company offering custom genetically engineered rodents together with in vivo pharmacology and AAV services, with operations in the US and China.
ZSHK Laboratories
Preclinical CRO with roots in a Chinese Academy of Sciences safety center, offering pharmacology, DMPK and safety evaluation with GLP operations in Shenzhen.
Questions to ask when choosing an In Vivo Pharmacology CRO
- Can you share historical and positive-control data for this model from the past year?
- How are animals randomized, and are efficacy readouts scored blind to treatment?
- Can PK and biomarker samples be taken from the same animals to build a PK/PD relationship?
- How was group size chosen, and has a power calculation been done for the primary endpoint?
- For biologics: has target cross-reactivity been confirmed in this species or strain?
In Vivo Pharmacology CRO FAQs
What does an in vivo pharmacology CRO do?
An in vivo pharmacology CRO tests whether a drug candidate works in a living animal model: that it reaches and engages its target, changes a disease-relevant endpoint, and does so at exposures that can be scaled to a human dose. Typical studies include efficacy in disease models, dose-response, PK/PD and target engagement, run before IND-enabling toxicology to decide which candidate moves forward.
Which CROs offer in vivo pharmacology for antibody programs?
Look for labs that list antibody programs alongside the models your target needs. Many therapeutic antibodies do not cross-react with the mouse target, so the work often relies on human target knock-in or humanized mice, immunodeficient mice engrafted with human immune cells, surrogate antibodies against the mouse target, or nonhuman primates when only primate cross-reactivity is available. Ask each lab which of these it runs and how it measures exposure of the antibody in the model.
How do you evaluate the quality of an in vivo pharmacology CRO?
Ask for validation data on the specific model, including historical control ranges and the response to a reference compound. Check that studies are randomized and blinded, that group sizes are based on a power calculation, and that exposure is measured in the same animals or a satellite group. AAALAC accreditation, model-specific experience and the willingness to share raw data are all useful signals.