Xenograft Model CROs

8 contract research organizations in our directory list Xenograft Models as a capability, across 4 countries. 1 reports GLP capability and 1 reports AAALAC accreditation. Compare their species, services and accreditations below, and contact labs directly from their profiles.

8 CROs 1 GLP 1 AAALAC 4 countries

About Xenograft Models

Cell line-derived xenografts (CDX) grow human cancer cell lines in immunodeficient mice, usually nude, SCID or NSG strains. They are fast, reproducible and relatively inexpensive, which makes them the standard first in vivo efficacy test for most oncology programs.

Tumors are usually implanted subcutaneously so they can be measured with calipers; orthotopic implantation in the organ of origin is used when the tumor environment or metastasis matters, often tracked by bioluminescence imaging. The main readouts are tumor growth inhibition, regression and time to endpoint, with PK and pharmacodynamic samples from tumor and plasma to connect exposure with effect.

Because cell lines adapt to culture over time, ask how the lab authenticates and tests its lines, and how many passages it allows. Randomization by tumor volume and blinded measurement reduce bias in what is often a noisy readout.

Preclinical oncology CROs →

Showing 8 CROs. Order rotates daily so no lab is permanently listed first.

Altogen Labs

US GLP

Texas preclinical CRO offering xenograft and other oncology models, efficacy, pharmacology and toxicology studies.

Xenograft Models In Vivo Efficacy Oncology Models Pharmacokinetics Toxicology Mouse Rat

Beviglia Cancer Models

US

Small niche oncology pharmacology CRO validating in vivo efficacy of cancer therapies in clinically predictive models.

Xenograft Models In Vivo Efficacy Oncology Models Mouse

Biomere

US Verified AAALAC

Biomere (a JOINN company) is a preclinical CRO based in Worcester, MA. Services include non-GLP PK/PD, discovery toxicology, surgical services, disease models, and laboratory sciences. Surgical services include…

Xenograft Models AAV Biodistribution Bioanalysis Bioavailability Studies Biodistribution Cynomolgus monkey Minipig Mouse Non-human Primate

Biocytogen

CN

Beijing-based company providing genetically engineered and humanized mouse models with in vivo pharmacology services, especially for oncology and immunology antibody programs.

Xenograft Models Antibody Programs In Vivo Efficacy Oncology Models Syngeneic Models Mouse

Antineo

FR

Lyon oncology CRO providing in vitro and in vivo proof-of-concept studies for anticancer agents, including resistant tumor models.

Xenograft Models In Vivo Efficacy Oncology Models Pharmacokinetics Syngeneic Models Mouse

Certis Oncology Solutions

US

San Diego oncology CRO offering patient-derived and orthotopic tumor models for in vivo efficacy and translational studies.

Xenograft Models In Vivo Efficacy Oncology Models PDX Models Mouse

Hera BioLabs

US

Kentucky CRO developing immunodeficient rat and mouse models, offering xenograft efficacy and safety studies in larger rodent hosts.

Xenograft Models In Vivo Efficacy Oncology Models PDX Models Toxicology Mouse Rat

Questions to ask when choosing a Xenograft Models CRO

  • Which cell lines do you have in-house, with growth curves and take rates in your hands?
  • How do you authenticate cell lines and test them for mycoplasma?
  • Do you randomize by tumor volume, and are caliper measurements blinded?
  • Can you run orthotopic or metastatic versions of the model with imaging?
  • Can tumor and plasma be collected for PK and biomarkers at defined time points?