Prisys Biotechnologies
Shanghai CRO centered on nonhuman primate efficacy and safety studies, with NHP disease models across metabolism, cardiovascular, renal, neurology and ophthalmology, clinical-style imaging and interventional surgery.
About Cynomolgus monkey
The cynomolgus macaque is the most widely used nonhuman primate (NHP) in preclinical safety testing. It is often the only pharmacologically relevant species for biologics, antibodies, oligonucleotides and gene therapies whose targets are not conserved in rodents or dogs, and it is the main NHP species for GLP toxicology, PK and CNS delivery studies.
Pharmacological relevance has to be shown, not assumed. Sponsors typically compare target sequence homology between human and cynomolgus, measure binding affinity to the human and cynomolgus targets side by side (for example by SPR or ELISA), and compare functional potency in cell-based assays using cells expressing each ortholog or primary cells from each species. For antibodies, tissue cross-reactivity and Fc receptor binding add to the case, and for oligonucleotides sequence identity at the target site is decisive. Comparable affinity and potency support use of the species under ICH S6(R1); large differences may mean adjusting doses or choosing another model.
NHP supply is constrained and study slots book well in advance, so confirming animal availability, sourcing and housing capacity early is as important as confirming technical capability. For gene therapy programs, animals are usually pre-screened for neutralizing antibodies to the AAV capsid. Our team has hands-on experience with NHP surgical models and CNS delivery routes, and we use it when reviewing labs that offer them.
Nonhuman Primate (NHP) CROs: Cynomolgus Monkey Studies
Showing 17 CROs. Order rotates daily so no lab is permanently listed first.
Shin Nippon Biomedical Laboratories (SNBL)
Long-established Japanese CRO with large GLP nonclinical safety facilities and deep nonhuman primate experience, supporting toxicology, safety pharmacology and pharmacokinetics.
Charles River Laboratories
Global preclinical/clinical CRO with extensive safety assessment, pharmacology, and discovery services.
ANEWCRO, LLC.
ANEWCRO is a nonclinical contract research organization (CRO) dedicated to providing innovative solutions and support to the biopharmaceutical industry, biotech startups and academic institutions. With unlimited access…
Texas Biomedical Research Institute
Independent nonprofit research institute with a national primate research center and high-containment labs, offering contract infectious disease, vaccine and NHP studies.
Labcorp Drug Development
Large CRO with global preclinical safety assessment, DMPK, and bioanalytical services.
Inotiv
Preclinical CRO offering discovery, DMPK, toxicology, surgical models, and specialty pathology.
K-Prime Research (BTT Group)
Korean nonhuman primate CRO in the Biotoxtech group with GLP repeat-dose toxicity and cardiovascular safety pharmacology in NHPs, plus NHP inhalation studies.
WuXi AppTec
Global R&D services including discovery, DMPK, toxicology, bioanalysis, and manufacturing support.
Cynbiose
Preclinical CRO near Lyon with core expertise in nonhuman primate models, including BSL-3 infectious disease, biodistribution and custom proof-of-concept studies.
BIOQUAL
Nonclinical CRO supporting infectious disease and other in vivo studies; bioanalysis and pathology support.
Altasciences
Integrated CRO/CDMO spanning preclinical to early clinical, including safety assessment and bioanalysis.
Lovelace Biomedical
Preclinical in vivo pharmacology and toxicology with aerosol/inhalation expertise.
Biomere
Biomere (a JOINN company) is a preclinical CRO based in Worcester, MA. Services include non-GLP PK/PD, discovery toxicology, surgical services, disease models, and laboratory sciences. Surgical services include…
ITR Laboratories Canada
Preclinical GLP toxicology and safety pharmacology across small and large species.
Alpha Genesis
Vertically integrated nonhuman primate CRO in South Carolina combining on-site breeding with discovery pharmacology, GLP toxicology, vaccine and gene therapy studies.
Preclinical Surgeon
With over 15 years of hands-on preclinical surgical experience, I deliver expert-level surgical support for in vivo studies across a broad range of therapeutic areas. I specialize in CNS drug delivery in nonhuman…
Questions to ask when choosing a Cynomolgus monkey CRO
- What is your current lead time for cynomolgus studies, and how are animals sourced?
- Can you run binding and functional assays against the cynomolgus target to confirm pharmacological relevance?
- Do you pre-screen animals for anti-AAV antibodies, and with what assay?
- Can you support the surgical models or routes your program needs in this species, such as intrathecal catheters or ICM dosing?
- What housing and enrichment standards apply, and are facilities AAALAC accredited?