StageBio
Specialty provider of GLP histology, necropsy, veterinary pathology evaluation, immunohistochemistry, neuropathology and specimen archiving for drug and device programs, with board-certified veterinary pathologists and…
About Pathology Services
Pathology is where most toxicology findings are confirmed or ruled out. Preclinical pathology services cover necropsy and tissue collection, histology processing, histopathological evaluation by veterinary pathologists, and clinical pathology: hematology, clinical chemistry, coagulation and urinalysis. The pathology report is often the most important section of a toxicology study.
Look for board-certified veterinary pathologists (ACVP, ECVP or JCVP) with experience in your species and organ system, and a formal peer review process for GLP studies. Specialized work, such as immunohistochemistry, neuropathology, ocular pathology or hard-tissue histology of implants, needs specific expertise, and CNS delivery studies benefit from perfusion fixation and careful evaluation of catheter tracts and injection sites.
Some sponsors use a separate contract pathology group alongside the in-life CRO, for primary evaluation or for peer review. If you do, agree on slide shipment, digital image and data transfer formats, including SEND datasets, at the outset.
Preclinical Pathology CROs
Showing 6 CROs. Order rotates daily so no lab is permanently listed first.
Experimental Pathology Laboratories (EPL)
Long-established provider of GLP histology and toxicologic pathology services, including peer review and pathology working groups, for preclinical safety studies.
Southern Research
Not-for-profit research institute in Birmingham, Alabama providing contract drug discovery and preclinical development, including infectious disease and BSL-3 work, oncology models, ADME, bioanalysis, toxicology and…
CVPath Institute
Cardiovascular pathology research institute providing GLP pathology evaluation of stents, valves and other vascular devices in preclinical studies.
Reveal Biosciences
Digital pathology and histology CRO offering IHC, whole-slide imaging and AI-based quantitative image analysis for preclinical and clinical tissue studies.
Flagship Biosciences
Tissue-based biomarker and digital pathology laboratory providing IHC, multiplex imaging and image analysis for drug development.
Questions to ask when choosing a Pathology Services CRO
- Who will be the study pathologist, what is their certification, and how much experience do they have with this species?
- How is pathology peer review handled, and is it contemporaneous or retrospective?
- Do you offer immunohistochemistry, special stains and digital whole-slide imaging in-house?
- For CNS or device studies, which fixation, sectioning and embedding methods do you use?
- Can you deliver SEND-compliant datasets for regulatory submission?