In Vitro CROs: Pharmacology, ADME and Safety Assays

2 contract research organizations in our directory list at least one of In Vitro Pharmacology, In Vitro ADME, hERG Assay or Genetic Toxicology, across 2 countries. 1 reports GLP capability and 2 report AAALAC accreditation. Compare their species, services and accreditations below, and contact labs directly from their profiles.

2 CROs 1 GLP 2 AAALAC 2 countries

About In Vitro

In vitro work tests compounds in cells, tissues and enzyme systems rather than whole animals. It is fast, inexpensive and well suited to ranking many compounds, so it dominates early discovery and continues through development as part of the regulatory package.

The main areas are in vitro pharmacology (binding, functional and enzyme assays that measure potency and selectivity), in vitro ADME (metabolic stability, permeability, plasma protein binding and CYP inhibition and induction), and in vitro safety, where the hERG assay addresses cardiac risk under ICH S7B and the Ames and in vitro micronucleus assays form the first part of the ICH S2(R1) genotoxicity battery.

Ex vivo assays sit between in vitro and in vivo work: tissues or blood taken from dosed animals, or from human donors, are tested outside the body. Examples include whole blood and PBMC assays, ex vivo receptor occupancy and brain slice electrophysiology. Many sponsors prefer an in vitro lab that also runs in vivo studies, so assays, species and data formats stay consistent when a compound moves into animals.

In vitro pharmacology CROs →

Showing 2 CROs. Order rotates daily so no lab is permanently listed first.

Biomere

US Verified AAALAC

Biomere (a JOINN company) is a preclinical CRO based in Worcester, MA. Services include non-GLP PK/PD, discovery toxicology, surgical services, disease models, and laboratory sciences. Surgical services include…

In Vitro Pharmacology AAV Biodistribution Bioanalysis Bioavailability Studies Biodistribution Cynomolgus monkey Minipig Mouse Non-human Primate

NeuroBridge

CN Verified GLP AAALAC

NeuroBridge Biotechnology is a specialized preclinical research organization based in Guangzhou, China, focused on non-human primate (NHP) and pig disease models and exploratory non-GLP translational studies. We support…

Genetic Toxicology In Vitro ADME AAV Biodistribution Acute Toxicity ADME Studies Cynomolgus monkey Minipig Non-human Primate Rhesus monkey

Questions to ask when choosing an In Vitro CRO

  • Which assays do you run in-house, and which do you subcontract?
  • Can you test the species orthologs of our target that match our in vivo models?
  • Are your hERG and genotoxicity assays available under GLP for regulatory submission?
  • Do you run ex vivo assays on samples from in vivo studies, such as receptor occupancy or whole blood assays?
  • What is your turnaround for a standard panel, and how are results delivered?