In Vitro Pharmacology CROs

4 contract research organizations in our directory list In Vitro Pharmacology as a capability, across 4 countries. 1 reports GLP capability and 1 reports AAALAC accreditation. Compare their species, services and accreditations below, and contact labs directly from their profiles.

4 CROs 1 GLP 1 AAALAC 4 countries

About In Vitro Pharmacology

In vitro pharmacology characterizes how a compound interacts with its target, and with everything else, before and alongside animal work. Core assays include radioligand and other binding assays to measure affinity, cell-based functional assays to measure potency and mode of action (agonist, antagonist or allosteric), and enzyme assays for enzymatic targets.

Selectivity and off-target profiling are where in vitro pharmacology feeds directly into safety. Broad panels of receptors, ion channels, transporters and enzymes flag liabilities early, and the hERG assay addresses cardiac risk as part of the ICH S7B package. Secondary pharmacology data are expected in an IND, so it pays to run panels while chemistry can still change course.

Many sponsors use the same CRO for in vitro pharmacology and in vivo efficacy, so potency, exposure and response can be interpreted together; others use a specialist screening lab. Either way, check that the in vitro assays use the same species of target as your in vivo models. A compound that is potent against the human receptor may be much weaker against the rat or mouse version.

ADME & pharmacokinetics guide →

Showing 4 CROs. Order rotates daily so no lab is permanently listed first.

Bioneer

DK

Danish non-profit research CRO offering customised cell models, assays and translational research services.

In Vitro Pharmacology Biomarker Analysis Method Development

Neuro-Sys

FR

French neuroscience CRO dedicated to in vitro and in vivo models of neurodegenerative and neurological disease, with a US office.

In Vitro Pharmacology CNS Disease Models In Vivo Efficacy Neurodegenerative Models Mouse Rat

Selvita

PL GLP

Polish drug discovery CRO providing integrated chemistry, biology, DMPK and translational research services.

In Vitro Pharmacology Bioanalysis In Vitro ADME In Vivo Efficacy Mouse Rat

Biomere

US Verified AAALAC

Biomere (a JOINN company) is a preclinical CRO based in Worcester, MA. Services include non-GLP PK/PD, discovery toxicology, surgical services, disease models, and laboratory sciences. Surgical services include…

In Vitro Pharmacology AAV Biodistribution Bioanalysis Bioavailability Studies Biodistribution Cynomolgus monkey Minipig Mouse Non-human Primate

Questions to ask when choosing an In Vitro Pharmacology CRO

  • Are your binding assays run with radioligands, fluorescence or label-free methods, and which reference compounds run on every plate?
  • Which species orthologs of our target can you test, so results match the in vivo model?
  • What does your standard off-target safety panel cover, and can it be extended for our chemical class?
  • Is hERG run by manual or automated patch clamp, and to what standard for regulatory submission?
  • What is your turnaround for a single concentration-response curve versus a full panel?