NeuroBridge
NeuroBridge Biotechnology is a specialized preclinical research organization based in Guangzhou, China, focused on non-human primate (NHP) and pig disease models and exploratory non-GLP translational studies. We support…
About ICM Administration
Intra-cisterna magna (ICM) administration delivers a test article into the CSF-filled cistern at the base of the skull. Compared with lumbar dosing it can give broader distribution to the brain surface and cerebellum, which has made it a common route for AAV and oligonucleotide programs.
Procedures range from a single percutaneous injection to an implanted catheter for repeat dosing and sampling. Technique, needle guidance and post-dose monitoring vary between labs, so experience with the specific species matters.
ICM Administration CROs
Showing 2 CROs. Order rotates daily so no lab is permanently listed first.
Biomere
Biomere (a JOINN company) is a preclinical CRO based in Worcester, MA. Services include non-GLP PK/PD, discovery toxicology, surgical services, disease models, and laboratory sciences. Surgical services include…
Questions to ask when choosing a ICM Administration CRO
- Is the procedure done percutaneously or via surgical exposure, and with what guidance?
- What is your maximum validated dose volume for this route and species?
- How do you monitor for and report procedure-related adverse effects?