2 contract research organizations in our directory list ICM Administration as a capability, based in US. 1 reports GLP capability and 2 report AAALAC accreditation. Compare their species, services and accreditations below, and contact labs directly from their profiles.
Intra-cisterna magna (ICM) administration delivers a test article into the CSF-filled cistern at the base of the skull. Compared with lumbar dosing it can give broader distribution to the brain surface and cerebellum, which has made it a common route for AAV and oligonucleotide programs.
Procedures range from a single percutaneous injection to an implanted catheter for repeat dosing and sampling. Technique, needle guidance and post-dose monitoring vary between labs, so experience with the specific species matters.
Showing 2 CROs. Order rotates daily so no lab is permanently listed first.
Preclinical CRO in West Michigan specializing in targeted CNS delivery. Long track record supporting intrathecal, intracerebroventricular and cisterna magna dosing, CSF and tissue distribution, pharmacokinetics and…
Biomere (a JOINN company) is a preclinical CRO based in Worcester, MA. Services include non-GLP PK/PD, discovery toxicology, surgical services, disease models, and laboratory sciences. Surgical services include…