Preclinical Surgeon
With over 15 years of hands-on preclinical surgical experience, I deliver expert-level surgical support for in vivo studies across a broad range of therapeutic areas. I specialize in CNS drug delivery in nonhuman…
About ICV Administration
Intracerebroventricular (ICV) administration delivers a test article into the lateral ventricles, giving direct access to the CSF and periventricular brain tissue. It is used for gene therapies, oligonucleotides, biologics and peptides that cannot cross the blood–brain barrier.
Dosing may be a single stereotaxic injection or repeated through an implanted cannula or reservoir. Rodents are common for early efficacy and distribution work; larger species are used when device, volume or translational anatomy matter.
ICV Administration CROs
Showing 5 CROs. Order rotates daily so no lab is permanently listed first.
Biomere
Biomere (a JOINN company) is a preclinical CRO based in Worcester, MA. Services include non-GLP PK/PD, discovery toxicology, surgical services, disease models, and laboratory sciences. Surgical services include…
ANEWCRO, LLC.
ANEWCRO is a nonclinical contract research organization (CRO) dedicated to providing innovative solutions and support to the biopharmaceutical industry, biotech startups and academic institutions. With unlimited access…
Northern Bio (Northern Biomedical Research)
Preclinical CRO in West Michigan specializing in targeted CNS delivery. Long track record supporting intrathecal, intracerebroventricular and cisterna magna dosing, CSF and tissue distribution, pharmacokinetics and…
PharmOptima
Michigan CRO offering in vivo ADME and pharmacokinetics, LC-MS/MS bioanalysis and biochemistry, with a niche in ocular drug development.
Questions to ask when choosing an ICV Administration CRO
- Do you use stereotaxic coordinates, imaging guidance, or both to target the ventricle?
- How do you confirm correct placement before and after dosing?
- What infusion volumes and rates have you validated in this species?