Preclinical Surgeon
With over 15 years of hands-on preclinical surgical experience, I deliver expert-level surgical support for in vivo studies across a broad range of therapeutic areas. I specialize in CNS drug delivery in nonhuman…
About Intrathecal Delivery
Intrathecal delivery places a test article directly into the cerebrospinal fluid of the subarachnoid space, bypassing the blood–brain barrier. It is central to preclinical programs for antisense oligonucleotides, AAV gene therapies and enzyme replacement therapies, where systemic dosing cannot reach the CNS at useful concentrations.
Studies range from single lumbar punctures to chronically implanted catheters with subcutaneous access ports for repeat dosing and CSF sampling. Nonhuman primates are the most common large-animal model because their spinal anatomy and CSF volume scale more closely to humans, but rodent, dog, pig and sheep models are also used. Our team has hands-on surgical experience with these procedures, and we use it to help sponsors judge which labs run them well.
Intrathecal Delivery CROs
Showing 4 CROs. Order rotates daily so no lab is permanently listed first.
ANEWCRO, LLC.
ANEWCRO is a nonclinical contract research organization (CRO) dedicated to providing innovative solutions and support to the biopharmaceutical industry, biotech startups and academic institutions. With unlimited access…
Biomere
Biomere (a JOINN company) is a preclinical CRO based in Worcester, MA. Services include non-GLP PK/PD, discovery toxicology, surgical services, disease models, and laboratory sciences. Surgical services include…
Northern Bio (Northern Biomedical Research)
Preclinical CRO in West Michigan specializing in targeted CNS delivery. Long track record supporting intrathecal, intracerebroventricular and cisterna magna dosing, CSF and tissue distribution, pharmacokinetics and…
Questions to ask when choosing an Intrathecal Delivery CRO
- What is your catheter patency rate over the planned study duration, and how is patency confirmed?
- How is catheter tip placement verified — imaging, contrast, or necropsy only?
- What CSF volume and sampling frequency can you support per animal?
- What are your post-operative complication rates, and how are affected animals handled in the study design?