Immunology CROs for Preclinical Studies

7 contract research organizations in our directory list at least one of Immunotoxicology, Syngeneic Models, Antibody Programs or Cell Therapy, across 5 countries. 3 report GLP capability and 1 reports AAALAC accreditation. Compare their species, services and accreditations below, and contact labs directly from their profiles.

7 CROs 3 GLP 1 AAALAC 5 countries

About Immunology

Preclinical immunology work falls into two groups. The first asks whether a drug harms or unintentionally activates the immune system. ICH S8 sets out immunotoxicity assessment, which typically starts with standard toxicology endpoints such as hematology, lymphoid organ weights and histopathology, and adds functional tests such as the T-cell dependent antibody response (TDAR), immunophenotyping by flow cytometry or NK cell activity when there is a signal or a mechanistic concern.

The second group asks whether a drug that targets the immune system works as intended. Immuno-oncology agents need models with a functioning immune system, such as syngeneic tumor models or humanized mice. Antibodies, bispecifics and engineered cell therapies need assays that measure immune cell activation, target engagement and cytokine release, often using human PBMC or whole blood in vitro alongside in vivo work. Autoimmune and inflammatory disease models, such as arthritis, colitis and experimental autoimmune encephalomyelitis, are offered by some labs; ask about them directly.

Flow cytometry capability is a good proxy for depth in this area: ask about panel size, validated species and whether the lab can analyze fresh samples on the day of collection.

CROs for antibody programs →

Showing 7 CROs. Order rotates daily so no lab is permanently listed first.

Burleson Research Technologies

US GLP

North Carolina CRO specializing in immunotoxicology, including GLP immune function assays for drugs, chemicals and biologics.

Immunotoxicology Immunogenicity Testing Toxicology Mouse Rat

Aurigon

HU GLP

Preclinical CRO with GLP laboratories near Budapest and offices in Munich, offering safety assessment, ADME-PK, bioanalysis and pharmacodynamic models.

Immunotoxicology Bioanalysis GLP Toxicology Pharmacokinetics Safety Pharmacology Dog Minipig Mouse Rabbit

Biotest Facility

DK

Independent Danish CRO focused on early in vivo pharmacology in rodents, with particular expertise in mouse cancer and immuno-oncology models.

Syngeneic Models In Vivo Efficacy Oncology Models Pharmacokinetics Mouse Rat

InnoStar

CN GLP AAALAC

Shanghai-based nonclinical CRO with GLP safety evaluation, pharmacology, DMPK, bioanalysis and biomarker services for small molecules, biologics and cell and gene therapies, operating several sites in China.

Cell Therapy Bioanalysis Biomarker Analysis Gene Therapy Studies GLP Toxicology Dog Mouse Non-human Primate Rat

genOway

FR

Lyon-based company creating genetically engineered and humanized rodent models, with catalog models and in vivo research services.

Antibody Programs In Vivo Efficacy Oncology Models Mouse Rat

Biocytogen

CN

Beijing-based company providing genetically engineered and humanized mouse models with in vivo pharmacology services, especially for oncology and immunology antibody programs.

Antibody Programs Syngeneic Models In Vivo Efficacy Oncology Models Xenograft Models Mouse

Antineo

FR

Lyon oncology CRO providing in vitro and in vivo proof-of-concept studies for anticancer agents, including resistant tumor models.

Syngeneic Models In Vivo Efficacy Oncology Models Pharmacokinetics Xenograft Models Mouse

Questions to ask when choosing an Immunology CRO

  • Do you run TDAR and immunophenotyping, and in which species?
  • Which immuno-oncology models do you offer: syngeneic, humanized mouse, or both?
  • Do you run in vitro cytokine release assays with human PBMC or whole blood?
  • What flow cytometry panels have you validated, and can samples be analyzed fresh?
  • Which autoimmune or inflammatory disease models do you run, and with what positive controls?