Preclinical CRO Services

Browse our comprehensive catalog of preclinical research services. Click any service to find CROs with that capability.

Toxicology

Safety assessment and regulatory toxicology studies

GLP Toxicology

Regulatory-compliant toxicology studies for IND submissions

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Acute Toxicity

Single-dose maximum tolerated dose (MTD) studies

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Repeat-Dose Toxicity

Subchronic and chronic toxicity assessments

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Genetic Toxicology

Ames, micronucleus, chromosomal aberration assays

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Reproductive Toxicity

Fertility, embryo-fetal, pre/postnatal development

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Immunotoxicology

Immune system effects and immunogenicity

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Pharmacology

Efficacy and mechanism of action studies

In Vivo Efficacy

Disease model proof-of-concept studies

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In Vitro Pharmacology

Receptor binding, enzyme assays, cell-based screens

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Dose-Response Studies

ED50, dose optimization, therapeutic window

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Target Engagement

Receptor occupancy, biomarker modulation

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ADME & Pharmacokinetics

Drug metabolism and disposition studies

In Vivo PK

Single and multiple dose pharmacokinetic studies

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In Vitro ADME

Metabolic stability, permeability, protein binding

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Metabolite Identification

Metabolite profiling and structural elucidation

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Toxicokinetics

Exposure assessment in toxicology studies

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Bioanalytical Services

Analytical method development and sample analysis

LC-MS/MS Analysis

Small molecule quantification by mass spectrometry

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Ligand Binding Assays

ELISA, MSD, Gyros for large molecules

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Method Development

Fit-for-purpose and validated method development

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Biomarker Analysis

Exploratory and validated biomarker assays

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Surgical & Specialty Models

Advanced surgical techniques and specialized delivery

Intrathecal Delivery

IT catheterization and CSF drug delivery

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ICV Administration

Intracerebroventricular delivery and cannulation

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ICM Administration

Intracisterna magna injection

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Intravitreal Injection

Ocular drug delivery and ophthalmology models

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Telemetry

Implantable cardiovascular and CNS telemetry

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Vascular Access

Catheterization, ports, and vascular surgery

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Safety Pharmacology

Core battery and follow-up safety studies

hERG Assay

Cardiac ion channel safety screening

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Cardiovascular Safety

In vivo CV telemetry and ECG studies

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Respiratory Safety

Pulmonary function and respiratory assessment

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CNS Safety

Neurobehavioral and functional observational battery

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Oncology

Cancer research and tumor model services

Xenograft Models

Human tumor xenografts in immunodeficient mice

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Syngeneic Models

Immunocompetent tumor models for I/O

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PDX Models

Patient-derived xenografts

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In Vivo Imaging

Bioluminescence, MRI, PET, CT imaging

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CNS & Neuroscience

Neurological disease models and CNS studies

CNS Drug Delivery

IT, ICV, ICM routes for CNS access

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Neurodegenerative Models

Alzheimer's, Parkinson's, ALS disease models

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Behavioral Assessment

Cognition, motor function, anxiety, depression

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Pain Models

Acute, chronic, neuropathic pain assessment

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Biologics & Gene Therapy

Large molecule and genetic medicine services

AAV Biodistribution

Gene therapy vector distribution studies

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Antibody Programs

Monoclonal antibody and bispecific studies

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Oligonucleotide Therapeutics

ASO, siRNA, mRNA therapeutic studies

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Cell Therapy

CAR-T and cell-based therapeutic studies

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Other Services

Additional preclinical capabilities

Pathology Services

Histopathology, clinical pathology, peer review

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Formulation Development

Dosing formulation and stability testing

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Regulatory Support

IND preparation and regulatory consulting

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Medical Device Testing

Biocompatibility and device safety studies

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