VectorBuilder
Vector design and manufacturing company that also offers AAV biodistribution profiling services, including barcoded multiplex studies in rodents and NHPs.
AAV Biodistribution CROs for Rat Studies
Showing 4 CROs. Order rotates daily so no lab is permanently listed first.
Biomere
Biomere (a JOINN company) is a preclinical CRO based in Worcester, MA. Services include non-GLP PK/PD, discovery toxicology, surgical services, disease models, and laboratory sciences. Surgical services include…
Northern Bio (Northern Biomedical Research)
Preclinical CRO in West Michigan specializing in targeted CNS delivery. Long track record supporting intrathecal, intracerebroventricular and cisterna magna dosing, CSF and tissue distribution, pharmacokinetics and…
Cyagen
Animal model company offering custom genetically engineered rodents together with in vivo pharmacology and AAV services, with operations in the US and China.
Questions to ask when choosing an AAV Biodistribution in Rat CRO
- Is your vector genome assay qPCR or ddPCR, and has it been qualified in every tissue on our panel?
- What lower limit of quantitation do you achieve per microgram of genomic DNA?
- How do you prevent cross-contamination at necropsy: collection order, dedicated instruments, separate areas?
- Can biodistribution be added to our toxicology study, or does it need a standalone cohort?
- Do you also run shedding, transgene expression and anti-AAV antibody assays, or are those sent out?
- For CNS routes, how do you confirm the dose was delivered where intended?